If you have experienced viral meningitis more than once, we would encourage you to ask your gp to investigate it to try and determine the cause. Mollarets meningitis benign recurrent aseptic meningitis. Pdf mollarets meningitis is a rare disease characterized by recurrent and selflimited episodes of lymphocytic meningitis. In this article a case of mollaret meningitis related to type 1 hsv is described. Mollaret s meningitis is a recurrent or chronic inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges. Get a printable copy pdf file of the complete article 869k. Mollaret meningitis, recurrent aseptic meningitis, fever.
Get a printable copy pdf file of the complete article 869k, or click on a page image below to browse page by page. Mollaret meningitis is a type of meningitis due to a viral infection aseptic meningitis that occurs multiple times. Cerebrospinal fluid csf examination remains the sole diagnostic modality. Linking to a nonfederal website does not constitute an endorsement by cdc or any of its employees of the sponsors or the information and products presented on the website. Since mollaret s meningitis is a recurrent, benign noncancerous, aseptic meningitis, it is also referred to as benign recurrent lymphocytic meningitis. However, recent research and studies have suggested that it may be more common than initially thought. Herpes simplex virus type 2associated recurrent aseptic. Recurrent aseptic meningitis secondary to intracranial epidermoid cyst and mollarets meningitis. It has been suggested that if the strict criteria above are followed, these cases should be excluded, and the term mollaret s meningitis reserved for true idiopathic cases. With this type of meningitis, there is usually rapid onset of symptoms and resolution without residual damage to the nervous system. Looking for online definition of mollaret meningitis in the medical dictionary. Mollarets meningitis fulltext european neurology 2008, vol. Canadian journal of neurological sciences journal canadien des sciences neurologiques, vol.
Mollarets meningitis also referred to as recurrent benign lymphocytic meningitis, is characterized by a transient and recurrent onset of neurological symptoms such as headaches, fever, meningismus and various neurological deficits that last for a few days in a selflimiting fashion. Herpes simplex type 2 virus is the causative agent in virtually all cases. Find mollarets meningitis information, treatments for mollarets meningitis and mollarets meningitis symptoms. The 35yearold praised simon read and matthew laws from the east of england ambulance service nhs trust eeast for their care after her condition rapidly deteriorated. We report a case of mollaret meningitis in a sevenyearold girl who presented with four aseptic meningitis episodes in one year. Mollarets meningitis and differential diagnosis of recurrent meningitis. In recent years there has been increasing evidence to implicate the herpes simplex virus 2 hsv2 in many cases. Recurrent lymphocytic meningitis rlm is a rare disease, characterized by attacks of sudden onset aseptic meningitis followed by complete recovery and unpredictable recurrences. Descrita por primera vez en 1944 por pierre mollaret como una meningitis endoteliolinfocitica recurrente caracterizada por presentarse en pacientes por lo demas sanos. In the original description of three patients with recurrent episodes of meningitis over a 15year period, the csf was notable for a leukocytosis and an unusual cell type originally thought to be of endothelial origin. Ideal sources for wikipedias health content are defined in the guideline wikipedia.
Mollarets meningitis mm is a rare disease of benign nature characterized by recurrent episodes of aseptic meningitis. Sep 02, 2016 mollaret meningitis is thought to be rare. Pdf on oct 1, 2004, christian wejse and others published picture of the month. Presented here is a new case of benign recurrent aseptic meningitis, or mollarets meningitis, in which cerebrospinal fluid was positive for herpes simplex virus type 2 using the polymerase chain reaction test. There are a number of risk factors for fungal meningitis, including the use of immunosuppressants such as after organ transplantation, hivaids, and the loss of immunity associated with aging. They bring forward evidence for the blastomatous nature of partly cornified epithelial cells present in their case. Presented here is a new case of benign recurrent aseptic meningitis, or mollaret s meningitis, in which cerebrospinal fluid was positive for herpes simplex virus type 2 using the polymerase chain. It is not known why one person gets meningitis when others exposed to the same germs do not get as sick, or dont get sick at all. Herpes simplex type 2 in a patient with mollarets meningitis.
Mollaret s meningitis has been characterized by unique abnormalities found on serial csf examinations. Mollaret meningitis genetic and rare diseases information. The trip database provides clinical publications about. Mollarets meningitis an overview sciencedirect topics. The disease is characterised by recurrent at least three episodes, benign no longterm sequelae and brief 25 day episodes of aseptic lymphocytic meningitis, alternating with symptomfree interval, mostly caused by hsv2 infection. Links with this icon indicate that you are leaving the cdc website the centers for disease control and prevention cdc cannot attest to the accuracy of a nonfederal website. Mollaret meningitis definition of mollaret meningitis by. Mollaret meningitis genetic and rare diseases information center. Meningitis is inflammation of the thin tissue that surrounds the brain and spinal cord, called the meninges. Recurrent aseptic meningitis secondary to intracranial. This is a rare condition believed to be caused in many cases by infection with a member of the herpes family of viruses.
Amanda has been living with mollarets meningitis a rare recurring viral form of the disease for more than six years. Benign recurrent aseptic meningitis mollarets meningitis. However, in contrast to bacterial meningitis, many patients with aseptic meningitis particularly those who have disease caused by viruses or. Mollarets meningitis is caused by herpes simplex virus. Get a printable copy pdf file of the complete article 869k, or click on a page image. Mollarets meningitis is a chronic recurrent form of herpes meningitis. Mollarets meningitis is characterized by recurrent episodes of severe headache, meningismus, and fever. Jan 25, 2019 mollaret meningitis is a type of meningitis due to a viral infection aseptic meningitis that occurs multiple times. Mollarets meningitisrecurrent aseptic meningitishsv2 virus. Jun 25, 2004 presented here is a new case of benign recurrent aseptic meningitis, or mollarets meningitis, in which cerebrospinal fluid was positive for herpes simplex virus type 2 using the polymerase chain reaction test. Aseptic meningitis often has a similar presentation to that of bacterial meningitis ie, fever, headache, altered mental status, stiff neck, photophobia, which can be a lifethreatening illness. Synonyms for mollaret meningitis in free thesaurus. Mollaret s meningitis mm is a rare disease of benign nature characterized by recurrent episodes of aseptic meningitis. Bacteria called neisseria meningitidis cause meningococcal disease.
Contribution to the background of mollarets meningitis. Mollaret s meningitis is felt to be rareso if you ve got a client with confirmed mollaret s. Mollarets meningitis and differential diagnosis of recurrent. Pdf on oct 1, 2014, zaw min and others published mollarets meningitis find, read and cite. Recurrent benign lymphocytic meningitis clinical infectious. Mollaret s meningitis is characterized by recurrent episodes of severe headache, meningismus, and fever. It is characterized by repeated episodes of meningitis, typically lasting two to five days, occurring weeks to years apart. Fulltext pdf recurrent aseptic meningitis with reversible cerebral vasoconstriction. A collection of disease information resources and questions answered by our genetic and rare diseases information specialists for mollaret. Mollaret s meningitis also referred to as recurrent benign lymphocytic meningitis, is characterized by a transient and recurrent onset of neurological symptoms such as headaches, fever, meningismus and various neurological deficits that last for a few days in a selflimiting fashion. Mollarets meningitis and herpes simplex virus type 1 nejm. Mollarets meningitis is a recurrent or chronic inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges. Recurrent meningitis rm is a rare condition classically known as mollarets syndrome2 defined by two or more episodes of.
Herpes simplex virus type 2associated recurrent aseptic mollarets meningitis in genitourinary medicine clinic. Mollarets meningitis caused by herpes simplex virus type. The clinical features in a patient with recurrent brief episodes of aseptic meningitis are described. Herpes simplex virus type 2associated recurrent aseptic mollaret s meningitis in genitourinary medicine clinic.
Pdf mollaret s meningitis is a rare disease characterized by recurrent and selflimited episodes of lymphocytic meningitis. Mollarets meningitis has been characterized by unique abnormalities found on serial csf examinations. About 1 in 10 people have these bacteria in the back of their nose and throat without being ill. Mollarets meningitis is the name given to a recurring form of meningitis. Mollaret was the first to describe a rare form of meningitis that presented as recurrent and brief selflimiting attacks of fever, headache, vomiting, and meningeal irritation with no obvious etiology. Mollaret syndrome definition of mollaret syndrome by. Mollaret s meningitis and differential diagnosis of recurrent meningitis. This syndrome is associated with transient neurological symptoms in onehalf of afflicted patients. Hendler n, schlaeffer f, zirkin h, rabinowitz b, berginer vm. The disease is most often caused by herpes simplex virus type 2 hsv2 and less frequently by other viruses, autoimmune disorders, or medication. Recurrent lymphocytic meningitis positive for herpes simplex.
Eighteen csf samples from 14 patients were studied along with the clinical data. Tell a friend about us, add a link to this page, or visit the webmasters page for free fun content. When initially described by mollaret, this form of aseptic meningitis had no identifiable infecting agent. Mollarets meningitis caused by herpes simplex virus type 2. Recurrent lymphocytic meningitis positive for herpes. Symptoms of mollaret meningitis, which last from 1 to 7 days, include headache, neck ache, fever, and neck stiffness. Mollaret meningitis synonyms, mollaret meningitis antonyms. Nov 01, 2006 recurrent benign lymphocytic meningitis is a recurring, typically innocuous, painful form of aseptic meningitis. Sometimes funguses, cancers, head injuries or other factors can cause meningitis, but cases from these sources are rare. Mollaret meningitis the turkish journal of pediatrics. Mollaret meningitis is characterized by three or more episodes of benign recurrent aseptic meningitis in which symptoms and signs resolve spontaneously. Mollaret meningitis article about mollaret meningitis by. We found the prevalence of recurrent lymphocytic meningitis associated with herpes simplex virus type 2 hsv2 was 2. They were identical to those in an entity known as mollarets.
Recurrent herpes simplex type 2 virus mollaret meningitis jabfm. Mollaret meningitis find, read and cite all the research you need on. Diagnosis, initial management, and prevention of meningitis. Mollaret s meningitis is a chronic recurrent form of herpes meningitis. Because of its rarity, it is difficult to estimate the exact number of individuals affected by this condition. Common signs and symptoms during an episode may include severe headache, fever, nausea, vomiting, sensitivity to light photophobia, and stiff neck. The interest is the demonstration of the herpes simplex virus type 1 within the. Full text full text is available as a scanned copy of the original print version. Pdf on oct 1, 2004, christian wejse and others published picture of the. Pcr was most sensitive in detecting hsv2 dna from cerebrospinal fluid if the sample was taken 25 days after symptom onset. An epidermoid cyst of the 3rd ventricle was verified by necropsy in a man of 60 with three episodes of mollarets aseptic leukocyticendothelial meningitis.
A rare form of aseptic meningitis characterized by a recurrent pattern with symptomfree intervals between episodes. Cases of idiopathic recurrent benign aseptic meningitis were first described by. Mollaret meningitis was first described by mollaret in 1944 as a form of aseptic meningitis. Mollarets meningitis the lancet infectious diseases. The peripheral white blood cell count alone is not help.
Presented here is a new case of benign recurrent aseptic meningitis, or mollarets meningitis, in which cerebrospinal fluid was positive for herpes simplex virus type 2 using the polymerase chain. You get it when a virus enters the body through the nose or mouth and travels to the brain. All three patients had shortlived attacks of fever, headache and vomiting, meningeal irritation, and generalized myalgia. Lol the disease is felt to be benign as much for the patient as it is to their contacts. Get a printable copy pdf file of the complete article 869k, or click on a page image below. Hsv2, less often hsv1 meningitis is clinically indistinguishable from cases of idiopathic mollarets meningitis 10, 11. Mollaret meningitis journal of the neurological sciences. You get it when a virus enters the body through the nose or mouth and travels. Mollaret s meningitis is caused by herpes simplex virus. Mollaret syndrome recurrent benign viral infection. We present a case of a 27yearold woman with mollarets meningitis related to viral infection with herpes simplex virus type 2 confirmed by cerebrospinal fluid.
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