Johnson et al reported the occurrence of 60% of the tumors in mandible, 30% in the form of peripheral calcifying odontogenic cysts and anterior part of the jaw was involved in 53% of cases9. Calcifying ghost cell odontogenic tumor cgcot was first described by gorlin et al. A,axial unenhanced ct scan shows a large, poorly marginated, lobulated softtissue mass causing irregular destruction of the body of the mandible, predominantly in the right. Consequently, the name clear cell odontogenic carcinoma was thought to be more appropriate in view of the malignant potential manifested by this neoplastic lesion 2022. The 2005 who histological classification of odontogenic tumors lays out a classification system for neoplasms and other tumors related to the odontogenic apparatus. Previous descriptions of this tumor were based on identification of malignant histologic characteristics such as infiltration, cellular pleomorphism, numerous mitoses, and necrosis concurrent with classical benign coc or its solid benign variant, the.
Gorlin nevoid basal cell carcinoma syndrome basal cell carcinomas in nonsun exposed areas. The calcifying ghost cell odontogenic cyst cgcoc was first described by gorlin et al. Chapter 21 odontogenic and nonodontogenic tumors of the jaws introduction. Ghost cell odontogenic carcinoma gcoc is a rare malignant variant of odontogenic tumor with ghost cells. It is more common in males with an age peak at the fourth decade of life 2. The odontogenic ghost cell carcinoma ogcc is the malignant counterpart of a calcifying cystic odontogenic tumor and dentinogenic ghost cell tumor. Some tumors are true neoplasms, while some are hamartomas developmental malformations. Ghost cell odontogenic carcinoma arising from calcifying. Odontogenic ghost cell carcinoma ogcc is a rare neoplastic variant of calcifying odontogenic cyst, with aggressive clinical characteristics. Ghost cell odontogenic carcinoma gcoc is the malignant counterpart of calcifying cystic odontogenic tumour and dentinogenic ghost cell tumour.
The most notable features of this pathologic entity are histopathological features which include a cystic lining demonstrating characteristic. The pathogenesis of this rare group remains still controversial and there have been many varied opinions over the classification of this rare group of lesions. On the basis of 52 examples of calcifying odontogenic cysts associated. Multiple basal cell carcinomas multiple jaw cysts odontogenic keratocysts numerous bone abnormalities including bi. Squamous cell carcinoma scc in a survey of dogs with oropharyngeal tumors, scc was the second most frequently diagnosed oral tumor 24. Background clear cell odontogenic carcinoma ccoc, which has been described within the past 2 decades, is a rare odontogenic tumor that tends to occur in the mandible of older adults, with a predilection for women. This is the case of a middleaged male who presented with a slowgrowing maxillary tumour. Odontogenic carcinoma arising from benign odontogenic. Clear cell odontogenic carcinoma ccoc is a rare intraosseous carcinoma of the jaw. Ledesmamontes c, gorlin rj, shear m, praetorius f, et al.
Feedback controls limit cell division after a certain number of cells have developed, allowing for tissue repair click the link for more information. Other less common odontogenic malignant tumors include ghost cell odontogenic carcinoma and primary intraosseous squamous cell carcinomas 1, 16. Pdf calcifying odontogenic cyst, dentinogenic ghost cell tumor. The clear cell variant of ceot can be mistaken for clear cell odontogenic carcinoma, some metastatic carcinoma, like renal cell carcinoma, and some salivary gland tumors like mucoepidermoid carcinoma and acinic cell carcinoma2. Explanations and recommendations of the guidelines from the international collaboration on cancer reporting. Primary malignant tumors of the jaws can arise from odontogenic epithelial remnants within the alveolar segment or from the transformation or degeneration of benign lesions. We report a case of a 70 yearold woman with a rapid onset of painful swelling right maxillary tumor. Calcifying ghost cell odontogenic cyst is comparatively rare in occurrence, constituting about 0. In 1992 who published the second edition of histological typing of odontogenic tumors. Ki67 and p53 expression in ghost cell odontogenic carcinoma. Ghost cell odontogenic carcinoma is an extremely rare odontogenic tumor with unclear etiology.
Ghost cell odontogenic carcinoma arising in the background of a benign calcifying cystic odontogenic tumor of the mandible. Pathogenesis and nomenclature of odontogenic carcinomas. The sqamous cell carcinoma should also be considered because of cytological pleomorphism and intercellular bridges2. This book greatly expands the body of knowledge in the field of odontogenic tumor pathology. Pdf background the aim of this study was to integrate the available data published on calcifying odontogenic cyst coc, dentinogenic ghost cell tumor. Odontogenic keratocysts make up around 19% of jaw cysts.
Clear cell odontogenic tumora new histologic variant with aggressive potential. Calcifying cystic odontogenic tumor a case report and. Odontogenic tumor article about odontogenic tumor by the. There have been very few reports about gcocs arising from. Clear cell odontogenic carcinoma mimicking a cystic lesion. Ghost cell odontogenic carcinoma gcoc is a rare malignant. It generally occurs in bone, and it has been postulated that the epithelium of origin is derived from one of the following sources. We report herein a case of a ghost cell odontogenic carcinoma arising in the mandible of a caucasian male 86 years of age. Ghost cell odontogenic carcinoma on right mandible and its. In two surveys of oropharyngeal tumors in cats the most frequently diagnosed tumor was scc, representing 6164% of the oral tumors. International collaborative study on ghost cell odontogenic tumours. Aggressive epithelial odontogenic ghost cell tumor in the.
We describe a case of gcoc which was considerably derived from a previously resected calcifying cystic odontogenic tumor ccot. In the whoiarc classification of head and neck pathology, this clinical entity had been known for years as the odontogenic. There are previous reports of ameloblastic carcinoma misdiagnosed as ameloblastoma and treated more conservatively, leading to poor treatment outcome. Calcifying ghost cell odontogenic tumor cgcot with. Morgan odontogenic tumors comprise a range of disorders of growth, from malignant and benign. A 70yearold woman presented with a large painful radiolucent mandibular lesion from the right canine to the left angle area through the midline. Martosfernandez m, alberolaferranti m, huetomadrid ja, bescosatin c. Odontogenic ghost cell carcinoma ogcc is a rare odontogenic tumor characterized by the presence of ghost cells.
Odontogenic tumors comprise a complex group of lesions with varied histopathological and clinical features. Calcifying epithelial odontogenic tumor of the maxilla. Odontogenic and nonodontogenic tumors of the jaws are a relatively rare and heterogeneous group of benign and malignant neoplasms, hamartomas, and other bonerelated lesions that demonstrate great variability in etiology, biologic behavior, and clinical significance. At the time of writing 2016, it is still the most widely used classification system although a new revision is due to come up in 2017. We have described the clinical and radiographic features, histological. Although known by many names, the basic histologic identifying feature includes the identification of the ghost cells and the malignant changes associated with the cells. Other tumours, such as calcifying epithelial odontogenic tumour pindborg tumour and ghost cell lesions, may comprise only about 1% of the total and are therefore very rarely seen. An odontogenic keratocyst is a rare and benign but locally aggressive developmental cyst. Ameloblastoma is a neoplasm of odontogenic epithelium, especially of enamel organtype tissue that has not undergone differentiation to the point of hard tissue formation. Some are composed only of odontogenic epithelium, while many are mixed i.
Nevoid basal cell carcinoma syndrome gorlin goltz syndrome ccot calcifying cystic odontogenic tumor derived from odontogenic epithelial cell rest. Odontogenic ghost cell carcinoma johns hopkins university. Odontogenic ghost cell carcinoma with pulmonary metastasis. Ghost cell odontogenic carcinoma gcoc is a rare malignant odontogenic tumor, only 37 cases of gcoc have been reported in the. It most often affects the posterior mandible and most commonly presents in the third decade of life. Squamous cell carcinoma arising within a maxillary. Mandibular clear cell odontogenic carcinoma world journal. Ameloblastoma, a type of odontogenic tumor involving ameloblasts. Ghost cell odontogenic carcinoma gcoc is an exceptionally rare and malignant odontogenic tumor with aggressive growth characteristics. Ghost cell odontogenic carcinoma med oral patol oral cir bucal.
Clear cell odontogenic carcinoma ccoc is a rare odontogenic tumor with predominance in the posterior mandible, usually occurring in the fifth to seventh decades of life, and being found more commonly in females. Odontogenic ghost cell carcinoma ogcc, a malignant counterpart of the calcifying odontogenic cyst coc, is exceedingly rare. The present report describes 2 cases of primary intraosseous squamous cell carcinoma. Ameloblastic carcinoma, calcifying odontogenic cyst, ghost cell carcinoma, keratinizing epithelial odontogenic cyst, maxillary tumor, odontogenic carcinoma. Primary intraosseous squamous cell carcinoma arising in. It is a potentially aggressive tumour, capable of recurring frequently, locally invasive, and with distant metastases. Clear cell odontogenic carcinoma ghost cell odontogenic carcinoma odontogenic sarcomas ameloblastic. Pdf ghost cell odontogenic carcinoma is a rare condition characterized by ameloblasticlike islands of epithelial cells with aberrant. Ghost cell odontogenic carcinoma arising in the background of a. Ghost cell odontogenic carcinoma gcoc was first described in detail as a malignant focus within a calcifying odontogenic cyst coc by ikemura et al.
Odontogenesis, odontogenic cysts, and odontogenic tumors. It describes the epidemiologic, radiologic, and histopathologic features of presently known neoplasms and hamartomatous or tumorlike lesions arising from the toothforming structures, as well as a number of distinctive jaw lesions that must be distinguished from odontogenic. Previous descriptions of this tumor were based on identification of malignant histologic characteristics such as infiltration, cellular pleomorphism, numerous mitoses, and necrosis concurrent with classical benign coc or its solid benign. Dentinogenic ghost cell tumor odontogenic ectomesenchymal odontogenic.
It is potentially aggressive and capable of multiple local recurrences and locoregional and distant metastases. Clinicopathological analysis of histological variants of. Case report mandibular ghost cell odontogenic carcinoma. The chart showing pdf series, word series, html series, scan qr codes.
He was asymptomatic until pain symptoms developed prior to initial presentation. Odontogenic carcinoma is rare group of malignant epithelial odontogenic neoplasms with characteristic clinical behavior and histological features, which requires an aggressive surgical approach. Ghost cell odontogenic carcinoma, aggressive epithelial ghost cell odontogenic tumor, dentinogenic ghost cell ameloblastoma, carcinoma arising in a coc, and malignant calcifying ghost cell odontogenic tumor 6. The distinct feature of this lesion is a cystic lining demonstrating ghost epithelial cells with a. Maxillary clear cell odontogenic carcinoma a rare entity. Odontogenic cysts can give rise to a variety of neoplasms. Ghost cell odontogenic carcinoma is a rare condition characterized by ameloblasticlike islands of epithelial cells with aberrant keratinitation in the form of ghost cell with varying amounts of dysplastic dentina.
D, frcpath assistant prof of general pathology senior lecturer of oral pathology and oral histology slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Although potentially locally destructive, okc is a benign odontogenic process that typically presents with clinical and radiographic features characteristic of a benign intraosseous neoplasm. Clear cell odontogenic tumor is a rare neoplasm of the jaws that histologically may be confused with metastatic renal cell carcinoma. Odontogenic tumors questions and study guide quizlet. Dentigerous cysts are one of the most common odontogenic cysts of the oral cavity. Chapter 21 odontogenic and non odontogenic tumors of the jaws introduction.
Odontogenic and non odontogenic tumors of the jaws are a relatively rare and heterogeneous group of benign and malignant neoplasms, hamartomas, and other bonerelated lesions that demonstrate great variability in etiology, biologic behavior, and clinical significance. Calcifying cystic odontogenic tumor ccot is defined as an odontogenic cyst like benign neoplasm that characteristically contains several. Until now, only 31 cases of ogccs have been reported in literature. An odontogenic tumor is a neoplasm of the cells or tissues that initiate odontogenic processes examples include. Avila, md2 1department of pathology philippine general hospital university of the philippines manila 2department of pathology college of medicine philippine general hospital university of the philippines manila. Odontogenic carcinoma arising from benign odontogenic cysts. Ghost cell odontogenic carcinoma gcoc is a rare malignant odontogenic epithelial tumor with features of benign calcifying odontogenic cysts. Data set for the reporting of malignant odontogenic tumors. Clear cell odontogenic carcinoma ccoc, clear cell odontogenic tumor previously called clear cell ameloblastoma considered benign by who of 1992, but due to its high potential for regional spread and distant metastases, it was reclassified as malignant in 2005. Squamous cell carcinoma scc arising within the lining of an odontogenic keratocyst okc is a rare occurrence.
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